Publications

PUBLICATION DESCRIBING THE VELOCIGENE PROCESS

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

Nat Biotechnol. 2003 Jun;21(6):652-9

Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA, Wang X, Su H, Xue Y, Dominguez MG, Noguera I, Torres R, Macdonald LE, Stewart AF, DeChiara TM, Yancopoulos GD

Abstracts

PUBLICATIONS THAT USE MICE GENERATED BY VELOCIGENE METHODS

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 Cell

2006 Jan 27;124(2):315-29

Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Mostoslavsky G, Murphy MM, Mills K, Hwei-Ling Cheng, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Mulligan R, Demple B, Yancopoulos GD and Alt FW

Abstracts

Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina

J Neurosci. 2006 Jan 25;26(4):1179-89

Amici SA, Dunn WA Jr, Murphy AJ, Adams NC, Gale NW, Valenzuela DM, Yancopoulos GD, Notterpek L

Cell Metab. 2005 Dec;2(6):421-7

Wortley K, Anderson K, Yasenchak J, Murphy A, Valenzuela D, Yancopoulos GD, Stanley J. Wiegand and Mark W. Sleeman

Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation

J Immunol. 2005 Nov 15;175(10):6605-14

Towne CF, York IA, Neijssen J, Karow ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Neefjes JJ, Rock KL

The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia

J Immunol. 2005 Oct 15;175(8):5341-50

Pope SM, Zimmermann N, Stringer KF, Karow ML, and Rothenberg ME

Functional Characterization of Mouse RDH11 as a Retinol Dehydrogenase Involved in Dark Adaptation in Vivo

J Biol Chem. 2005 May 27;280(21):20413-2

Kasus-Jacobi A, Ou J, Birch DG, Locke KG, Shelton JM, Richardson JA, Murphy AJ, Valenzuela DM, Yancopoulos GD, Edwards AO

PUBLICATIONS THAT USE MICE GENERATED BY VELOCIGENE METHODS

Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus

Neuron. 2005 May 19;46(4):647-60

Choi GB, Dong HW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Swanson LW, Anderson DJ

Abstracts

Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2496-501

Macdonald LE, Wortley KE, Gowen LC, Anderson KD, Murray JD, Poueymirou WT, Simmons MV, Barber D, Valenzuela DM, Economides AN, Wiegand SJ, Yancopoulos GD, Sleeman MW, Murphy AJ

Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity

Nat Med. 2005 Feb;11(2):199-205

Sleeman MW, Wortley KE, Lai KM, Gowen LC, Kintner J, Kline WO, Garcia K, Stitt TN, Yancopoulos GD, Wiegand SJ, Glass DJ

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development

Proc Natl Acad Sci U S A. 2004 November; 101(45): 1594915954

Gale NW, Dominguez MG, Noguera I, Li Pan, Hughes V, Valenzuela DM, Murphy AJ, Adams NC, Hsin Chieh Lin, Holash J, Thurston G, and Yancopoulos GD

Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8227-32

Wortley KE, Anderson KD, Garcia K, Murray JD, Malinova L, Liu R, Moncrieffe M, Thabet K, Cox HJ, Yancopoulos GD, Wiegand SJ, Sleeman MW

Recognition of single-stranded RNA viruses by Toll-like receptor 7

Proc Natl Acad Sci U S A. 2004 April; 101(15): 55985603

Lund JM, Alexopoulou L, Ayuko Sato, Karow M, Adams NC, Gale NW, Akiko Iwasaki, and Flavell RA

Identification of ubiquitin ligases required for skeletal muscle atrophy

Science. 2001 Nov 23;294(5547):1704-8. Epub 2001 Oct 25

Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ

September 7, 2006
VelociGene technology selected for the NIH Knockout Mouse Project (KOMP)

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Regeneron Will Use its VelociGene® Technology to Target Genes, Providing New Models of Human Disease.

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Fastest from concept to Knockout mice without sacrificing precision and complexity.

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VelociGene allows scientists to rapidly identify the physical and biological effects of deleting or over-expressing the target gene. View Slideshow